Excited to share our latest paper on the enigmatic kinase ERK5, identifying part of its unique signalling role in endothelial cells.
mdpi.com/2073-4409/12/6… Cells MDPI Inst of Systems, Molecular & Integrative Biology
#ERK5 , #vascular , #EndothelialCell , #angiogenesis
Early career seminar at the USC School of Medicine Columbia CARDIOVASCULAR TRANSLATIONAL RESEARCH CENTER
It was a pleasure to share knowledge.
Camilla Ferreira Wenceslau
#vascular #perivascular #hypertension #skeletalmuscle #vsmc #endothelialcell
Super grateful to be recognized at this year’s program #ATDG46 ! Special thanks to Joanna Kalucka Steno Diabetes Center Aarhus, Aarhus University, and Danish Diabetes and Endocrine Academy for supporting me in my research #adiposetissue #Endothelialcell
#EndothelialCell TGFβR2 is essential for autocrine VEGF-A (major source in injured lung) & LRG1 to ⏫ #MicrovascularRegeneration in📷
Gan Zhao Lulu Xue, Ph.D Mike Mitchell Andy Vaughan also on bluesky Science Translational Medicine
2024 science.org/doi/10.1126/sc…
My continued biomedical education
Specialized Pro-resolving Mediators in vascular inflammation and atherosclerotic cardiovascular disease
Lipoxin
Resolvin
Protectin
Maresin
#EndothelialCell - #Neutrophil coordination in SPM biosynthesis🤠
⏫Macrophage #efferocytosis #MERTK …
Genome-wide enhancer-gene regulatory map (variant-to-gene-to-program; Perturb-seq for 306 #CoronartArteryDisease GWAS loci)▶️a central role of #EndothelialCell in CAD pathophysiology
CCM2 (polarity) & TLNRD1 (actin bundling)⏬ endothelial shear sensing & barrier integrity!…
Katrin Laakmann @katrinBe236 nicely presented her work on the impact of bacterial #extracellularvesicles on #endothelialcell function at #DGP2024 #DGPneumo #EVenthusiasts German Society for Extracellular Vesicles
Tie2
⏫VE-PTP endocytosis
⏬ #VascularPermeability
AND this occurs at the flow downstream in an individual #EndothelialCell
EC VE-PTP KO or AKB‐9785 (VE-PTP inhibitor) ⏬Apoe-/-🐭 #Atherosclerosis
Donald McDonald & Dietmar Vestweber labs EMBO Mol. Medicine 2023
embopress.org/doi/full/10.15…
#NAVBO member publication alert
T cell-dependent bispecific antibodies alter organ-specific #EndothelialCell –T cell interaction
Dr. Patricia Himmels & Weilan Ye group Genentech EMBO Reports 2023
embopress.org/doi/full/10.15…
New in the current issue of Function: 'Mitochondrial ATP Production is Required for Endothelial Cell Control of Vascular Tone' by Wilson et al.
ow.ly/6jWc50NZgCe
#EndothelialCell #mitochondria
Arrhythmic Flow (Piezoelectric pump+Microfluidics ibidi GmbH µ-slide) on human aortic #EndothelialCell
4 or 20 dyne/cm2
Variations at amplitude/frequency to disrupt the rhythmicity of Pulsatile flow
Arrhythmicity->
No effects on flow-induced alignment
⏫EC spreading…
🩺 Drs. Elizabeth Mason (Lizzie Mason), Benjamin Hogan (@BenjaminHogan13) and team provides new mechanistic insights into the enigmatic role of transcription factor Prox1 and the control of #lymphatic #EndothelialCell differentiation in development
📎 bit.ly/3yIeco0
☕️Our October issue's here!
👑Bonus for my #stemcell / #devbio friends:
✌️🏽A distinct #bonemarrow #endothelialcell (Yoshiaki Kubota & co)
✌️🏼 #epidermalcell #dedifferentiation (Watt & co)✌️🏿human #germline commitment (Surani & co)
✌️ Resource on human #spermatogenesis (Zhao & co)
🥂Congrats to Yoshiaki Kubota, Takubo & co for their new Open Access study in our journal (@NatureCellBio) identifying a #BoneMarrow #EndothelialCell subtype that contributes to bone strength acquisition and offers a distinct #HematopoieticStemCell niche.
nature.com/articles/s4155…
#NCB2023 (Nature Cell Biology) #stemcell / #devbio :
In October, Yoshiaki Kubota, Takubo & co performed #scRNAseq and found a distinct #BoneMarrow #EndothelialCell type that contributes to #bone strength and offers a distinct #hematopoietic stem cell niche.
nature.com/articles/s4155…
Looking for an easy way to stay up to date on #EndothelialCell News? 🧐 Check out the Science News website by STEMCELL Tech and subscribe to our weekly newsletters covering the latest research, reviews, industry news, and more. 👇
bit.ly/3Yrj9fp
Indirect immunostaining of methanol postfixed mouse brain fresh frozen section with guinea pig anti-Tight junction protein ZO-1 antibody (red) and mouse anti-Aquaporin 4 antibody (green). Nuclei have been visualized by DAPI staining (blue). #endothelialcell
#DiabetesMellitus and #TobaccoChewing may alter #CornealEndothelialHexagonality and reduce #EndothelialCell counts. Research in Eye Journal
Read here: fal.cn/3y2BC
#TobaccoUse #IntraocularSurgery #Optometry #EyeHealth
