👃🏼🧬💡Candidate therapies are PI3K/mTOR inhibitors for ITAC, EGFR and CDK4/6 inhibitors for SNSCC, MEK inhibitors for MMM, IDH2 inhibitors for SNUC/SNEC/ONB, and EZH2 inhibitors for SNUC/TCS;DNA repair and FGFR inhibitors may be considered for other sinonasal tumor subtypes

🎙Score genomic 🔄 local failure for #brainmetastase
📌570 👥w/1,487 BM➡️WBRT OR SRS
OncoPanel for all 👥
👉11 genes (ATM, MYCL, PALB2, FAS, PRDM1, PAX5, CDKN1B, EZH2, NBN, DIS3, MDM4) 🔄⬇️LF
👉2 genes (FBXW7 & AURKA) 🔄⬆️LF
👉Brain-RPS developed w/ genes
👉RPS🔄LF in MVA

Great wrap-up at #AACR24 ! Big thanks to all who joined us to explore immune interception strategies for Lynch-related colorectal cancer via EZH2 inhibition. #CancerPrevention #EZH2 #LynchSyndrome #Vilarlab

EZH2 cooperates with gain‐of‐function p53 mutants to promote cancer growth and metastasis
embopress.org/doi/full/10.15…

To remember the features of Weaver syndrome, use the word 'WEAVER':

Wide-set eyes 👀
EZH2 variants
Advanced bone age 🩻
oVERgrowth (tall stature, macrocephaly, macroglossia)

#GeneChat

Inhibition de Ezh2 pour améliorer les perturbations du métabolisme lipidique et la fonction cardiaque post-IDM par Hugues Boël au 17ème printemps de la cardiologie. EnVI lab FHU CARNAVAL GRRC -French community in cardiovascular research

Do you want to know about the role of EZH2, an epigenetic target that modulates compulsive alcohol intake? Come by my poster this morning, monday 14th #SS14 #SfN2023
❗️My lab is hiring! Open postdoc position #epigenetics #braincircuits #anxiety #alcohol 🧠🍺

Come check out the exciting new work by Yusuke on EZH2 inhibition and CART activity against lymphoma! #ASH2023

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma ashpublications.org/blood/article-… # EZH1 and EZH2 inhibitor (Valemetostat) in T cell leukemia and lymphoma

オンコロでは、局所進行・再発類上皮肉腫患者を対象としたEZH2阻害薬タゼメトスタットの多施設共同第II相医師主導治験のご案内をしています。

詳細はこちら
oncolo.jp/ct/ad0111

#肉腫 #類上皮肉腫 #希少がん #EZH2阻害薬 #タゼメトスタット #治験

Congratutalations to Neha Mehta-Shah for her SIP award from Siteman Cancer Center -Phase I Study with Expansion Cohort of EZH2 Inhibitor Tulmimetostat in Patients with Mycosis Fungoides and Sézary Syndrome

WashUOncology WUSM Department of Medicine Washington U. Med Forum for Women in Medicine at WashU (FWIM)
siteman.wustl.edu/siteman-invest…

EZH2 mutations associated with lower response to CD19 CAR-T cells: great talk from ⁦Marco Ruella⁩ #CART24

Really nice to hear so much from another EZH2 fan 😍 beautiful work, and congrats on winning the oral poster presentation!! Well deserved!! @Ammarilys

【 #糖尿病 治疗突破】澳大利亚贝克心脏与 #糖尿病 研究所的一个研究小组对FDA已批的一种药物（针对人体组织中EZH2酶）的新用途进行研究，发现此药可在48小时内使 #胰岛素 分泌再生，这是糖尿病患者的福音。
sciencealert.com/diabetes-break…

Congratulations to UCLA Neurosurgery 🧠 resident Dr. Josh Casaos on his outstanding #AANS2023 talk & 2023 SBTF award winning work on EZH2 inhibition in the treatment of meningioma.

New paper from the lab reveals a link between epigenetic therapy-induced viral mimicry and NFAT:AP1 signaling. Rationale for combining DNMT and EZH2 inhibitors in colon cancer. Thankful to ⁦National Cancer Institute⁩ and ⁦ACS Research⁩ for supporting our work! science.org/doi/10.1126/sc…

New in #HumPathol : TP53 mutation is frequent in mantle cell lymphoma with EZH2 expression and have dismal outcome when both are present. sciencedirect.com/science/articl… #pathology #PathTwitter #hemepath

Better late than never. Excited to share our new paper with the French Lab where we discover that EZH2 cooperates with BRD4-NUT to drive oncogenesis! aacrjournals.org/cancerres/arti…

Congratulations to Sara Ovejero 👏 presenting EZH2 and NSD2/MMSET interactions in Multiple Myeloma. #ASH2023 .
InstituteHumGenetics Université de Montpellier CHU de Montpellier Faculté de Médecine Montpellier-Nîmes Institut universitaire de France (IUF)

Exciting to see our data from ⁦NCI CTEP Clinical Research⁩ trial #10183 presented here at #GU23 ⁦ASCO⁩! Pilot study of #tazemetostat & #pembrolizumab . We are trying to see if #EZH2 and #PD1 can help patients with #bladdercancer !